The skin model should be free of contamination by bacteria, viruses, mycoplasma, or fungi.
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Immunity—Langerhans cells in the skin are dendritic cells that take up microbial antigens in the skin to transform into anti-gen presenting cells and provide immunity by interacting with T cells. The name Lang-erhans comes from the German physician and anatomist that discovered these cells in the skin when he was a medical student.
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